Andrew Bynum – Los Angeles Lakers
Bynum’s rookie season was off and running in lightning fashion, until the 2007–08 season. On January 13, he suffered a horrific knee injury during a game against the Memphis Grizzlies. Bynum partially dislocated his left kneecap after he landed awkwardly on teammate Lamar Odom’s left foot while attempting to grab a rebound. He missed the following 32 games of that season and re-injured the knee the following year, missing the start of the next season. After this, he is still plagued with knee problems.
Jamal Lewis – Baltimore Ravens
Jamal Lewis was rather unlucky considering the entire nation witnessed his defining knee injury on HBO’s “Hard Knocks” during a training camp following Baltimore’s Super Bowl run in 2000. He ended up missing the entire 2001 season but (!) he returned and played better than ever. Lewis had rushed for 2,066 yards to lead the league and fell just 39 yards short of Eric Dickerson’s all-time single-season record.